An investigational H1 influenza oral tablet vaccine was found to provide similar protection against influenza as an injectable quadrivalent influenza vaccine (QIV) in a Phase 2 clinical trial.
The trial participants were randomized to receive either a single dose of Vaxart oral tablet vaccine and a placebo intramuscular injection, a QIV injection plus a placebo tablet, or a double placebo. They were challenged intranasally with homologous A strain influenza virus 90–120 days after vaccination. Laboratory-confirmed homologous influenza A infections were compared among the groups.
Results showed that the tablet vaccine provided a 39% reduction in clinical disease relative to placebo, compared to a 27% reduction with injectable QIV. The tablet also demonstrated a safety profile similar to placebo.
“These results provide clinical proof-of-concept for Vaxart’s groundbreaking oral tablet vaccine technology,” said Wouter Latour, MD, MBA, CEO of Vaxart, in a press release. “A convenient and effective tablet vaccine could significantly increase current vaccination rates and generate important public health benefits for at-risk groups and the population as a whole.”
Over 80 percent of children who died from flu last year were not vaccinated.
Flu vaccines are available, and so that means that the anti-vaccine brigade is out in force.
The Daily Mail published an anti-vaccine op-ed by a former reality TV contestant named Katie Hopkins. It was followed by a shorter counter argument by a doctor, but when you are given less than half the word count and are at the bottom of the page it is hard to mount an effective response. Hopefully the Daily Mail will give us an op-ed next week on how the earth is flat.
I noticed many responses to Ms. Hopkins on Twitter were from people who claimed that they previously caught the flu from the vaccine.
So one more time, for all the kids in the back: The flu vaccine does not cause influenza.
The flu vaccine is made with an inactivated virus that cannot cause illness or with a process using a recombinant technology that contains no virus at all.
If you get sick right after the flu vaccine one of the following has happened:
You have a cold, and you have mistaken it for the flu.
You have the flu, but you were incubating it before the vaccine. The vaccine takes about two weeks to work.
You have the flu and were unlucky enough to get a strain not covered by the vaccine.
You have the flu, and it is a strain that is covered by the vaccine, but you did not get as sick as you would have without the vaccine.
Nocebo effect. You expected something bad to happen and so your body produced symptoms.
If you aren’t sure, it is the flu let me tell you it isn’t the flu. With the flu, you really feel as if you are going to die. It’s that bad. I had it several years ago, and for two days I had to crawl to the bathroom. I was too weak to walk.